Tuesday, March 11, 2008

MISFISHIE Specification (for in situ hybridization and immunohistochemistry) now available

Under the leadership of Eric Deutsch, a specification for annotating In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE) has just been published in Nature Biotechnology.

Deutsch EW, Ball CA, Berman JJ, Bova GS, Brazma A, Bumgarner RE, Campbell D, Causton HC, Christiansen JH, Daian F, Dauga D, Davidson DR, Gimenez G, Goo YA, Grimmond S, Henrich T, Herrmann BG, Johnson MH, Korb M, Mills JC, Oudes AJ, Parkinson HE, Pascal LE, Pollet N, Quackenbush J, Ramialison M, Ringwald M, Salgado D, Sansone SA, Sherlock G, Stoeckert CJ Jr, Swedlow J, Taylor RC, Walashek L, Warford A, Wilkinson DG, Zhou Y, Zon LI, Liu AY, True LD. Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol. 2008 Mar;26(3):305-12.

MISFISHIE is modelled after the MIAME (Minimum Information About a Microarray Experiment) specification for microarray experiments.

It has been a constant theme in this blog that data specifications are, in many instances, much better than data standards. Data specifications, like MIAME and MISFISHIE specify the information content without dictating a format for encoding that information.

Nature Biotechnology put up the entire MISFISHIE specification for public comment, and it is currently available at:


- Jules Berman
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases.

I urge you to read more about my book. There's a generous preview of the book at the Google Books site. If you like the book, please request your librarian to purchase a copy of this book for your library or reading room.

tags: common disease, orphan disease, orphan drugs, genetics of disease, disease genetics, rules of disease biology, rare disease, pathology,annotation, data sharing, data specifications